Eire make seven adjustments, with Dan Sheehan captaining the facet for the primary time within the absence of Caelan Doris, who misses out with a knee damage.
Sheehan replaces the injured Ronan Kelleher at hooker, whereas Jack Conan is available in for Doris at eight.
Prop Thomas Clarkson makes a primary Take a look at begin, Jamie Osborne wins a primary Six Nations cap at 15, Mack Hansen returns from damage and Garry Ringrose is most popular to Bundee Aki.
Joe McCarthy can be recalled following damage, with James Ryan, Finlay Bealham and Bundee Aki dropping to the bench.
Uncapped Leinster prop Jack Boyle is included in a matchday squad for the primary time.
Eire: 15-Osborne, 14-Hansen, 13-Ringrose, 12-Henshaw, 11-Lowe; 10-S Prendergast, 9-Gibson-Park; 1-Porter, 2-Sheehan (capt), 3-Clarkson, 4-J McCarthy, 5- Beirne, 6-O’Mahony, 7-Van der Flier, 8-Conan.
Replacements: 16-G McCarthy, 17-Boyle, 18-Bealham, 19-Ryan (Leinster), 20-C Prendergast, 21-Murray, 22-Crowley, 23-Aki.